Journal article
Evaluating the cost-effectiveness of [18F]FDG-PET/CT for investigation of persistent or recurrent neutropenic fever in high-risk haematology patients
M Tew, AP Douglas, J Szer, A Bajel, SJ Harrison, SY Tio, LJ Worth, RJ Hicks, D Ritchie, MA Slavin, KA Thursky, K Dalziel
Cancer Imaging | BMC | Published : 2023
Abstract
Background: A recent randomised trial demonstrated [18F]fluorodeoxyglucose positron-emission tomography in combination with low-dose CT (FDG-PET/CT), compared to standard of care computed tomography (CT) imaging, positively impacted antimicrobial management and outcomes of acute leukaemia and haematopoietic stem cell transplant recipients with persistent and recurrent neutropenic fever. We conducted an economic evaluation from a healthcare perspective alongside the clinical trial. Methods: Unit costs in Australian dollars were applied to all resources used (antimicrobials, diagnostic tests, ICU and hospital bed days). Effectiveness was measured as number of patients with antimicrobial ration..
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Awarded by University of Melbourne
Funding Acknowledgements
The National Centre for Infections in Cancer is supported by a National Health and Medical Research Council (NHMRC) Centre of Research Excellence grant (APP1116876). A Melbourne Health foundation and Gilead Research Fellowship grant also supported this study. AD is supported by a University of Melbourne PhD scholarship. We would like to thank the dedicated nursing and medical staff on both haematology wards for their hard work and excellent teamwork. Thank you to the NCIC research team who contributed significantly to the running of this study. Thank you to the Peter MacCallum Cancer Centre Pharmacy staff who assisted in helping with the costing to antimicrobials.